AI-enabled EDC & eCRF platform for RWE

Evidence that moves medicine.

LM EvidenceBridge unifies your entire RWE lifecycle — from protocol design to peer-reviewed publication — across pharma sponsors, CROs, hospital sites, and regulators on a single connected platform. 27 modules. 4 workspaces + patient portal. Zero silos.

One platform · Every stage

Built for the full RWE lifecycle

From first protocol draft to regulatory submission and peer-reviewed publication — every workflow, every stakeholder, every data standard in one place.

27 modules

Protocol & Study Design

eCRF builder, amendment tracking, visit schedule design, multi-arm study configuration, and registry linkage.

AI

AI-Enabled eCRF Data Capture

Role-gated structured data entry with SDV indicators, DCF query management, calculated fields, edit checks, and electronic lock & sign.

New

Retrospective Chart Upload

PDF/image upload pipeline for retrospective studies: OCR extraction, AI field mapping, CRA review & approval, and participant linkage.

Safety: AE, SUSAR & ConMeds

CTCAE grading, SAE flags, regulatory reporting clocks, authority notification matrix, and WHO ATC-coded concomitant medications.

Statistical Analysis (SAP)

MMRM, Kaplan–Meier, Cox regression, propensity score matching with 14 covariates, and multiplicity correction gating.

Visit & Survey Management

Protocol-driven visit matrix, window tracking, missed-visit alerts, and multi-visit PRO trend analysis (PHQ-9, EQ-5D-5L, SF-36).

CFR-11

Audit Trail & Compliance

Tamper-evident audit log with before/after diffs, e-signature hash, IP address, actor identity, and reason for change.

Medical Writing & CSR

ICH E3 / CTD 5.3.5.1 CSR drafting, STROBE checklist, CRediT authorship taxonomy, journal selector, and eCTD XML export.

API

FHIR / OMOP / CDISC Export

One-click export to FHIR R4 Bundles, CDISC ODM 1.3.2, OMOP CDM v5.4, SDTM domains, Flat CSV, and SAS XPT.

Global

Regulatory-Grade Compliance

21 CFR Part 11, ICH E6(R3), EMA RWE framework, PMDA guidance, and regional data privacy regulation alignment out of the box.

Patient Portal & eConsent

Token-based patient portal with QR self-registration, eConsent with countersign, medication diary, AE self-reporting, and caregiver proxy access.

Three steps from research question to evidence

A structured, compliance-first workflow that keeps every stakeholder aligned and every data point audit-ready.

01

Design & Setup

Protocol authoring, SAP definition, eCRF builder, visit schedule, site selection, investigator training, and ethics documentation.

02

Capture & Monitor

Multi-site eCRF data entry, retrospective chart upload with OCR, visit tracking, real-time query management, and safety surveillance.

03

Analyse & Publish

Statistical analysis, clinical study report drafting, regulatory submission packages, journal submission, and post-market evidence.

Retrospective Chart Review

Turn paper charts into structured RWE data — automatically.

The Microsite Admin portal manages the entire retrospective upload pipeline: drag-and-drop PDF/image upload, AI-powered OCR extraction, field mapping review, CRA approval, and patient-level linkage — all in a Study → Site → Patient hierarchy.

  • Upload PDF, JPEG, or TIFF charts — batch or individual, per patient
  • AI OCR extracts structured fields with confidence scoring
  • 4-stage pipeline: uploaded → extracted → confirmed → CRA approved
  • Per-site analytics: upload velocity, OCR accuracy, approval backlog
  • Full audit trail on every status transition and field correction

Upload Pipeline · AIIMS Delhi

4

Uploaded

8

Extracted

6

Confirmed

14

Approved

PT-001Discharge Summary

OCR confidence: 94%

approved

PT-002Lab Reports Q3

OCR confidence: 87%

confirmed

PT-003Outpatient Notes

OCR confidence: 72%

extracted
Safety & Pharmacovigilance

Real-time safety surveillance — never miss a regulatory deadline.

Automated SUSAR detection with configurable reporting clocks, authority notification matrices, CTCAE v5.0 grade assignment, and causality assessment — built for both commercial and academic RWE studies worldwide.

  • CTCAE Grade 1–5 with SAE flag and relatedness assessment
  • Configurable regulatory reporting clocks per jurisdiction
  • Concomitant medications coded to WHO ATC 2024
  • Full AE narrative with action taken and resolution tracking
  • Authority notification matrix with submission status tracking

Safety Monitoring · Study RWE-001

Diabetic Ketoacidosis

SUSAR · Unexpected

Final

✓ Reported Day 6

Acute Kidney Injury G3

SUSAR · Unexpected

Follow-up

7d deadline: 1d remaining

Hypovolaemia Grade 3

SUSAR · Unexpected

Final

✓ Reported Day 5

8

Total AEs

3

SAEs

3

SUSARs

Audit Trail · 21 CFR Part 11

FIELD_UPDATE

Dr. R. Sharma · HbA1c → 7.2%

09:12
ESIGN

Dr. R. Sharma · Baseline CRF

09:13
DATA_LOCK

DM: P. Menon · Visit M3 Forms

14:07
SUSAR_CREATE

PV: A. Reddy · SUSAR-002

16:31
EXPORT

Study Manager · OMOP CDM v5.4

10:00

21 CFR Part 11 · §11.10(e) · Tamper-evident · SHA-256 e-signature

Audit & Compliance

21 CFR Part 11 and ICH E6(R3) — built in, not bolted on.

Every field change, signature, and export is captured in a tamper-evident audit trail with SHA-256 e-signature hashing, IP address logging, and before/after data diffs. Inspection-ready from day one.

  • Tamper-evident audit log: who, what, when, where, why
  • Electronic signatures with SHA-256 hash per 21 CFR §11.100
  • ALCOA+ attributes: attributable, legible, contemporaneous, original, accurate
  • ICH E6(R3) GCP alignment with version-controlled document control
  • Configurable for FDA, EMA, PMDA, and other regulatory frameworks
Patient Portal

Patients as active participants — not passive subjects.

The EvidenceBridge patient portal gives study participants direct, secure access to their consent, diary, visit schedule, and AE reporting — all from any mobile browser via a QR code. No app download. No password.

  • QR code or unique link access — token-based, no login required
  • eConsent with view-duration tracking and typed-name confirmation
  • Daily medication adherence diary with missed-dose reason capture
  • Patient-reported AE submission with real-time coordinator alert
  • Caregiver proxy access with patient-delegated permission

Patient Portal · Study Participant

eConsent

EMPA-RWE-001 · Version 2.0 · English

Data Collection
Sample Storage
Future Research
Commercial Use
Viewed: 4m 32sSigned · 14 Jul 2026

23

Diary Entries

68

Doses Logged

1

AEs Reported

3 / 7

Visits Done

QR

Access via QR code

No app · No password · Any device

4 Workspaces + Patient Portal

The right view for every stakeholder

Pharma sponsor, operations, hospital site, microsite admin, and patient — each gets a purpose-built workspace with role-scoped access and zero over-sharing.

Operations

Internal operations team workspace for platform administration, data management, statistical analysis, and medical writing.

Roles

Platform AdminData ManagerBiostatisticianMedical WriterFinance ManagerQA Auditor

Key Modules

Data Management
Statistical Analysis
Medical Writing
Compliance
Cohort Builder
FHIR Ingestion
PSM / IPW
Audit Logs
Sponsor Workspace

Pharma, CRO, and medical affairs workspace for study oversight, site management, analytics, and publication.

Roles

Portfolio DirectorStudy ManagerTenant AdminCRA ManagerCRAMedical MonitorPharmacovigilance

Key Modules

Studies & Portfolio
Study Designer
Site Feasibility
Investigator Tracking
Recruitment
Data Quality
Analytics
Reports
Hospital Workspace

Site-scoped workspace for investigators and coordinators — only the patients and visits assigned to your facility.

Roles

Principal InvestigatorSub-InvestigatorStudy CoordinatorResearch NurseEthics ReviewerQA Auditor

Key Modules

Site-Scoped Patients
Visit Matrix
eCRF Data Capture
Safety (AE/SUSAR)
Query Management
Ethics
Documents
Microsite Admin Portal

Purpose-built portal for retrospective chart review: upload, OCR extraction, CRA approval, and patient-level analytics — all in a Study → Site → Patient hierarchy.

Roles

Microsite AdminCRAData Manager

Key Modules

Study & Site Browser
Chart Upload Pipeline
OCR Extraction Review
CRA Approval Queue
Per-site Analytics
Participant Linkage
Query Management
Patient Portal

Token-based patient portal — no app, no password. Patients access via QR code or unique link from their coordinator.

Roles

PatientCaregiver (Proxy)

Key Modules

eConsent & Withdrawal
Daily Diary
Medication Adherence
AE Self-Report
Visit Schedule
Document Upload

Regulatory & interoperability standards

21 CFR Part 11ICH E6(R3) GCPEMA RWE FrameworkCDISC ODM 1.3.2CDISC SDTMOMOP CDM v5.4FHIR R4 (HL7)ICH E3 CSRICH E9(R1) SAPSTROBE ReportingCTCAE v5.0WHO ATC 2024CRediT AuthorshipeCTD XML

Built for every role on the study team

Each persona gets a tailored experience with exactly the data, tools, and workflows they need.

Principal Investigator

Your site, your patients — nothing beyond your remit.

  • Site-scoped patient matrix filtered to your enrolled participants only
  • Visit window tracker with closing alerts and 'Enter Data' shortcuts
  • One-click AE/SUSAR reporting with regulatory notification status
  • Pending e-signature queue and delegation log
  • Study-level safety dashboard with CTCAE grades and causality

0

Platform modules

0+

Roles across 4 workspaces

0%

ALCOA+ data coverage

0.9%

Platform uptime SLA

API-First Architecture

Your data, your warehouse, your format.

Every study is accessible via authenticated REST API. Export to your sponsor's data warehouse in FHIR R4, OMOP CDM, CDISC SDTM, or flat CSV with per-study rate limits and full audit trail of every export.

FHIR R4CDISC ODM 1.3.2OMOP CDM v5.4CDISC SDTMFlat CSVSAS XPTJSON Summary
REST API · Export

# Export as FHIR R4 Bundle

GET /api/v1/studies/rwe-001/export/fhir

Authorization: Bearer sk_live_****

{

"resourceType": "Bundle",

"total": 234,

"entry": [ Patient · Observation · Condition ]

}

White Paper · 2026

From Fragmented Data to Regulatory-Grade Evidence

A platform guide for RWE study leaders on eliminating silos, accelerating timelines, and producing publication-ready evidence at scale.

LM EvidenceBridge
Free White Paper

From Fragmented Data to Regulatory-Grade Evidence

A 28-page strategic guide for study directors, biostatisticians, and clinical operations leads on how purpose-built RWE platforms eliminate data silos, compress timelines, and deliver inspection-ready evidence.

Why most RWE studies miss their timelines
The real cost of fragmented tooling
Platform selection criteria checklist
Global regulatory alignment (FDA, EMA, PMDA)
FHIR · OMOP · CDISC interoperability guide
ROI model: cost and time savings

Want to read instead? Request read access →

Personalised, no commitment

See EvidenceBridge with your study loaded.

In a 45-minute session, we'll walk through your indication, visit schedule, site structure, and reporting requirements — live on the platform.

  • Custom eCRF configured to your protocol
  • Multi-site visit matrix with your site list
  • Retrospective upload pipeline demo (if applicable)
  • Safety and pharmacovigilance setup walkthrough
  • Export formats aligned to your regulatory target

Book your demo

No commitment. Response within one business day.